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Advances in Alzheimer's and Parkinson's Disease.pdf Advances in Behavioral Biology ADVANCES IN BEHAVIORAL BIOLOGY Editorial Board Jan Bures Institute of Physiology, Prague, Czech Republic Irwin Kopin National Institute of Mental Health, Bethesda, Maryland Bruce McEwen Rockefeller University, New York, New York Karl Pribram Radford University, Radford, Virginia Jay Rosenblatt Rutgers University, Newark, New Jersey Lawrence Weiskranz University of Oxford, Oxford, England Recent Volumes in this series Volume 46 BIOLOGYANDPHYSIOLOGYOFTHEBLOOD-BRAINBARRIER: Transport, Cellular Interactions, and Brain Pathologies Edited by Pierre-Olivier Couraud and Daniel Scherman Volume 47 THE BASAL GANGLIA V Edited by Chihoto Ohye, Minoru Kimura and John S. Mckenzie Volume 48 KINDLING 5 Edited by Michael E. Corcoran and Solomon Moshé Volume 49 PROGRESS IN ALZHEIMER’S AND PARKINSON’S DISEASES Edited by Abraham Fisher, Israel Hanin and Mitsuo Yoshida Volume 50 NEUROPSYCHOLOGY OF CHILDHOOD EPILEPSY Edited by Isabelle Jambaqué, Maryse Lassonde and Olivier Dulac Volume 51 MAPPING THE PROGRESS OF ALZHEIMER’S AND PARKINSON’S DISEASE Edited by Yoshikuni Mizuno, Abraham Fisher and Israel Hanin Volume 52 THE BASAL GANGLIA VI Edited by Louise F.B. Nicholson and Richard L.M. Faull Volume 53 CATECHOLAMINE RESEARCH: From Molecular Insights to Clinical Medicine Edited by Toshiharu Nagatsu, Toshitaka Nabeshima, Richard McCarty and David S. Goldstein Volume 54 THE BASAL GANGLIA VII Edited by Ann M. Graybiel, Mahlon R. Delong and Stephen T. Kitai Volume 55 KINDLING 6 Edited by Michael E. Corcoran and Solomon L. Moshé Volume 56 THE BASAL GANGLIA VIII Edited by J. Paul Bolam, Cali A. Ingham and Peter J. Magill Volume 57 ADVANCES IN ALZHEIMER’S AND PARKINSON’S DISEASE Edited by Abraham Fisher, Maurizio Memo, Fabrizio Stocchi and Israel Hanin A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher Abraham Fisher l Maurizio Memo l Fabrizio Stocchi l Israel Hanin Editors Advances in Alzheimer’s and Parkinson’s Disease Insights, Progress, and Perspectives Editors Abraham Fisher Israel Institute for Biological Research IIBR, Ness-Ziona Israel Maurizio Memo Universitá degli Studi di Brescia 25124 Brescia Italy Fabrizio Stocchi Universitá La Sapienze Roma 86077 Pozilli, Isernia Italy Israel Hanin Loyola University Stritch School of Medicine Department of Pharmacology Maywood, IL 60153-5589 USA Library of Congress Control Number: 2007930197 ISBN 978-0-387-72074-6 ISBN 978-0-387-72076-0 Printed on acid-free paper # 2008 Springer Science+Business Media, LLC All rights reserved. This workmay not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC., 233 Spring Street, New York, NY10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. 9 8 7 6 5 4 3 2 1 springer.com ...