2010_非小细胞肺癌.pdf
2010_非小细胞肺癌.pdf
Copyright © National Comprehensive Cancer Network 2010. All rights reserved. “NCCN”, the NCCN logo, and “National Comprehensive Cancer Network” are registered
trademarks of the National Comprehensive Cancer Network.
The Chinese edition of NCCN Clinical Practice Guidelines in Oncology-Non-Small Cell Lung Cancer Guideline 2010 is the Chinese adapted version of NCCN Clinical
Practice Guidelines in Oncology-Non-Small Cell Lung Cancer Guideline, V.2.2010 as permitted and endorsed by NCCN. It is the collaborative outcome of the National
Comprehensive Cancer Network and Chinese key opinion leaders of the field.
The original guideline and Chinese edition are both available at: http://www.nccn.org. To view the most recent and complete version of the guideline, go online to
www.nccn.org. These Guidelines and illustrations herein may not be reproduced in any form for any purpose without the express written permission of the NCCN.
These Guidelines are a work in progress that will be refined as often as new significant data becomes available. The NCCN Guidelines are a statement of consensus of its
authors regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult any NCCN guideline is expected to use independent
medical judgment in the context of individual clinical circumstance to determine any patient's care or treatment. The National Comprehensive Cancer Network makes no
warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.
This publication should not be used for commercial purpose. It is provided for free to Chinese medical professions with the support of the unrestrictive educational grant of
Shanghai Roche Pharmaceuticals Ltd. which exerts no influence to the formation of the Chinese edition of NCCN Clinical Practice Guidelines in Oncology-Non-Small Cell
Lung Cancer Guideline 2010.
NCCN ® 肿瘤学临床实践指南(中国版)2010年 第一版
© National Comprehensive Cancer Network, Inc. All rights reserved. These guidelines and this illustration may not be reproduced in any form without the express written permission of NCCN.
The Chinese edition 2010 is the collaborative outcome of the National Comprehensive Cancer Network and Chinese key opinion leaders of the field. Translated and adapted with permission and endorsement from the National Comprehensive
Cancer Network. To view the most recent and complete version of this or any other guideline, visit www.nccn.org.
非小细胞肺癌
NCCN非小细胞肺癌专家组成员
* David S. Ettinger, MD/Chair †
The Sidney Kimmel Comprehensive Cancer Center at
Johns Hopkins
Wallace Akerley, MD †
Huntsman Cancer Institute at the University of Utah
Gerold Bepler, MD, PhD †
H. Lee Moffitt Cancer Center & Research Institute
Matthew G. Blum, MD ¶
Robert H. Lurie Comprehensive Cancer Center
of Northwestern University
Andrew Chang, MD ¶
University of Michigan Comprehensive Cancer Center
Richard T. Cheney, MD ≠
Roswell Park Cancer Institute
Lucian R. Chirieac, MD ≠
Dana-Farber/Brigham and Women's Cancer Center
Thomas A. D’Amico, MD ¶
Duke Comprehensive Cancer Center
Todd L. Demmy, MD ¶
Roswell Park Cancer Institute
Apar Kishor P. Ganti, MD †
UNMC Eppley Cancer Center at The Nebraska Medical
Center
Ramaswamy Govindan, MD †
Siteman Cancer Center at Barnes-Jewish Hospital and
Washington University School of Medicine
Frederic W. Grannis, Jr., MD ¶
City of Hope Comprehensive Cancer Center
Thierry Jahan, MD †
UCSF Helen Diller Family Comprehensive Cancer Center
Mohammad Jahanzeb, MD †
St. Jude Children’s Research Hospital/University of
Tennessee Cancer Institute
David H. Johnson, MD †
Vanderbilt-Ingram Cancer Center
Anne Kessinger, MD †
UNMC Eppley Cancer Center at The Nebraska
Medical Center
Ritsuko Komaki, MD §
The University of Texas M. D. Anderson Cancer
Center
Feng-Ming Kong, MD, PhD §
University of Michigan Comprehensive Cancer
Center
Mark G. Kris, MD †
Memorial Sloan-Kettering Cancer Center
Lee M. Krug, MD †
Memorial Sloan-Kettering Cancer Center
Quynh-Thu Le, MD §
Stanford Comprehensive Cancer Center
Inga T. Lennes, MD †
Massachusetts General Hospital Cancer Center
* Renato Martins, MD †
Fred Hutchinson Cancer Research Center/Seattle
Cancer Care Alliance
Janis O’Malley, MD ф
University of Alabama at Birmingham
Comprehensive Cancer Center
Raymond U. Osarogiagbon, MD †
St. Jude Children’s Research Hospital/University of
Tennessee Cancer Institute
Gregory A. Otterson, MD †
Arthur G. James Cancer Hospital & Richard J. Solove
Research Institute at The Ohio State University
Jyoti D. Patel, MD ‡
Robert H. Lurie Comprehensive Cancer Center of
Northwestern University
Katherine M Pisters, MD ¶ †
The University of Texas M. D. Anderson Cancer Center
Karen Reckamp, MD, MS †
City of Hope Comprehensive Cancer Center
Gregory J. Riely, MD, PhD †
Memorial Sloan-Kettering Cancer Center
Eric Rohren, MD, PhD ф
The University of Texas M. D. Anderson Cancer Center
George R. Simon, MD †
Fox Chase Cancer Center
Scott J. Swanson, MD ¶
Dana-Farber/Brigham and Women's Cancer Center
Douglas E. Wood, MD ¶
Fred Hutchinson Cancer Research Center/Seattle
Cancer Care Alliance
Stephen C. Yang, MD ¶
The Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins
† 肿瘤内科
¶ 外科/肿瘤外科
§ 肿瘤放射科/放疗科
≠ 病理科
‡ 血液科/血液肿瘤科
ф 诊断/介入放射科
* 编委会成员
NCCN ®非小细胞肺癌
© National Comprehensive Cancer Network, Inc. All rights reserved. These guidelines and this illustration may not be reproduced in any form without the express written permission of NCCN.
The Chinese edition 2010 is the collaborative outcome of the National Comprehensive Cancer Network and Chinese key opinion leaders of the field. Translated and adapted with permission and endorsement from the National Comprehensive
Cancer Network. To view the most recent and complete version of this or any other guideline, visit www.nccn.org.
肿瘤学临床实践指南(中国版)
2010年 第一版
NCCN特别鸣谢
NCCN指南中国版专家组
召集人：
孙 燕
中国医学科学院北京协和医学院
肿瘤医院
NCCN代表：
David S. Ettinger, MD
The Sidney Kimmel Comprehensive
Cancer Center at Johns Hopkins
NCCN非小细胞肺癌临床实践指南（中国版）专家组
组长：
廖美琳
上海交通大学附属胸科医院
成员（按拼音排序）：
程 刚
北京医院
储大同
中国医学科学院北京协和医学院肿瘤医院
韩宝惠
上海交通大学附属胸科医院
蒋国
复旦大学附属肿瘤医院
焦顺昌
中国人民解放军总医院（三○一医院）
李 凯
天津医科大学附属肿瘤医院
李龙芸
中国医学科学院北京协和医学院北京协和医院
陆 舜
上海交通大学附属胸科医院
朴炳奎
中国中医研究院广安门医院
执笔人：
张 力
中山大学附属肿瘤医院
秘书：
王子平
中国医学科学院北京协和医学院肿瘤医院
石远凯
中国医学科学院北京协和医学院肿瘤医院
王 洁
北京大学临床肿瘤学院、北京肿瘤医院
王绿化
中国医学科学院北京协和医学院肿瘤医院
王长利
天津医科大学附属肿瘤医院
吴一龙
广东省人民医院
支修益
首都医科大学肺癌诊疗中心
周彩存
同济大学附属上海市肺科医院
周清华
天津医科大学总医院
NCCN ® 肿瘤学临床实践指南(中国版)2010年 第一版
© National Comprehensive Cancer Network, Inc. All rights reserved. These guidelines and this illustration may not be reproduced in any form without the express written permission of NCCN.
The Chinese edition 2010 is the collaborative outcome of the National Comprehensive Cancer Network and Chinese key opinion leaders of the field. Translated and adapted with permission and endorsement from the National Comprehensive
Cancer Network. To view the most recent and complete version of this or any other guideline, visit www.nccn.org.
非小细胞肺癌
目录
NCCN非小细胞肺癌专家组成员
NCCN特别鸣谢
肺癌的预防和筛查（PREV-1）
基线评估和临床分期（NSCL-1）
评估和治疗：
● 0期（Tis）和隐匿性肺癌（TX, N0, M0）（NSCL-16）
● I期（T1~2, N0）和II期（T1~2, N1）（NSCL-2）
● IIB期（T3, N0）和IIIA、IIIB期（T3~4, N1）（NSCL-4）
● IIIA期（T1~3, N2）和分散的肺结节（NSCL-6）
● IIIB期（T1~3, N3）（NSCL-9）
● IIIB期（T4侵犯心脏等, N2~3）和IV期（胸腔或心包积液）（NSCL-10）
● IV期（M1b：单个转移灶和多发转移）（NSCL-11）
● 随诊（NSCL-12）
第二原发性肺癌（NSCL-16）
复发和转移的治疗（NSCL-12）
● 病理评估原则（NSCL-A）
● 外科治疗原则（NSCL-B）
● 放射治疗原则（NSCL-C）
● 辅助化疗方案（NSCL-D）
● 化放疗方案（NSCL-E）
● 晚期或转移性NSCLC的全身治疗（NSCL-F）
● 癌症幸存者照护（NSCL-G）
分期
讨论
参考文献
临床试验：NCCN认为任何肿瘤患者都可以在临床试验中得到最
佳处理，因此特别鼓励肿瘤患者参加临床试验研究。
NCCN对证据和共识的分类：
除非特别指出，NCCN对所有建议均达成2A类共识。
见NCCN证据和共识的分类
声明：
本指南中标注“※”处为中国专家根据国内实际情况进行明显改
动或补充之处，内容有别于英文版，参考时请注意。
指南更新概要
作为共识，NCCN肿瘤学临床实践指南反映了作者们对目前认可的治疗方法的观点，欲参考或应用这些指南的临床医师应根据个人具体的临床情况做出独立的医疗判断，以决定患者所需的护理和治
疗。任何寻求使用这些指南的病人或非医生人员应咨询医生关于它们的合理应用。
NCCN肿瘤学临床实践指南编译力求精确表达反映原版英文指南。NCCN不保证指南编译的有效性，也不承认任何无限制性的担保、表达及暗示。NCCN不担保指南编译或指南本身的精确性和完整
性。NCCN不保证或担保或陈述指南的应用及应用结果。NCCN及其成员不对涉及指南无限制性应用的任何偶然的、间接的、特殊的、惩罚性或作为结果的补偿费承担任何责任。
...
