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The.Cancer.Handbook.pdf huangzhiman For www.dnathink.org 2003.3.18 The Cancer Handbook The Cancer Handbook Contents Section A - The Molecular Basis of Cell and Tissue Organisation Section B - The Causation and Prevention of Cancer Section C - Diagnostic Imaging and Image-Guided Intervention Section D - Systemic Oncology Section E - Pre-clinical Models for Human Cancer Section F - The Treatment of Human Cancer Section A - The Molecular Basis of Cell and Tissue Organization 1. Cell and Tissue Organisation 2. Regulation of the Cell Cycle 3. Overview of Oncogenesis 4. Inherited Predispositions to Cancer 5. DNA Viruses 6. RNA Viruses 7. Genetic Instability and DNA repair 8. Telomerase 9. Apoptosis 10. Signalling by steroid receptors 11. Signalling by cytokines 12. Signalling by tyrosine kinases 13. Signalling by TGF beta 14. Wnt Signal Transduction 15. Extracellular Matrix: the networking solution 16. Invasion and Metastasis 17. Angiogenesis 18. Cell Proliferation in Carcinogenesis back to top Section B - The Causation and Prevention of Cancer 1. Identifying Cancer Causes through Epidemiology 2. Mechanisms of Chemical Carcinogenesis 3. The Formation of DNA Adducts 4. Physical Causes of Cancer 5. Non-Genotoxic Causes of Cancer 6. Infectious Agents and Cancer 7. Short-term Testing for Genotoxicity 8. Cancer Bioassays for Pharmaceuticals a Regulatory Perspective 9. Molecular Epidemiology of Cancer 10. Dietary Genotoxins and Cancer 11. Tobacco Use and Cancer 12. Occupational Causes of Cancer 13. Anti-Genotoxins and Cancer 14. Intervention and Chemoprevention back to top Section C - Diagnostic Imaging and Image-Guided Intervention Part I- Imaging Modalities in Diagnosis and Monitoring 1. Plain Film Radiography 2. Computed Tomography 3. Ultrasound 4. Magnetic Resonance Imaging 5. Nuclear Medicine Studies 6. Mammography Part II - Diagnostic and Therapeutic Interventional Procedures 1. Percutaneous Biopsy 2. Transcatheter Therapy 3. Direct Percutaneous Tumour Therapy back to top Section D - Systemic Oncology 1. Introduction to the Diagnosis of Cancer 2. Skin 3. Oral cavity & major and minor salivary glands 4. Respiratory tract 5. Upper Gastrointestinal tract 6. Lower gastrointestinal tract 7. Liver, gall bladder and extrahepatic bile ducts. 8. Pancreas 9. Endocrine organs 10. Breast 11. Female reproductive system 12. Urinary tract 13. Male reproductive system 14. Lymph nodes, spleen and bone marrow. 15. Bones and joints. 16. Soft Tissues 17. Pleura and peritoneum 18. Heart 19. Neuromuscular System 20. Eye and ocular adnexa 21. Ear Appendum. Myeloid Leukemias and related Neoplasms back to top Section E - Pre-clinical Models of Human Cancer 1. Advantages and limitations of models for human cancer 2. Basic Tissue Culture 3. Transgenic technology in the study of oncogenes and Tumor Suppressor Genes 4. Gene knockouts 5. Human tumours in animal hosts 6. Mammary tumour induction in animals as a model for human breast cancer 7. Mathematical models in cancer research 8. Models for tumour growth and differentiation 9. Angiogenesis models 10. Models for tumour cell adhesion and invasion 11. Tumour metastasis models 12. Models for tumour cell-endothelial cell interactions 13. Modelling Tumor Tissue Interactives 14. Models for drug development and drug resistance 15. Models for immunotherapy and cancer vaccines 16. Gene therapy models 17. Models for epithelial carcinomas 18. Models for haematological malignancies 19. Models for melanomas and sarcomas 20. Models for CNS malignancies 21. Models for endocrine cancer back to top Section F - The Treatment of Human Cancer 1. Mechanisms of action of cancer chemotherapeutic agents 2. Drug Resistance & Reversal 3. Molecular mechanisms of radiotherapy 4. Antibodies and recombinant cytokines 5. Genetic and Cellular Vaccines 6. Differentiation Therapy 7. Chemoprevention 8. Antisense & ribozyme therapy 9. Hormonal Therapy 10. Antiangiogenic Therapy 11. Targeting the Extracellular Matrix 12. Growth Factor Receptor Blockade 13. Signal Transduction pathway targeting 14. Cell cycle and DNA repair as targets for therapy 15. Gene Therapy - tumour suppressor replacement/oncogene suppression 16. Genetic Prodrug Activatron Therapy (GPAT) 17. Stem cell transplantation 18. Novel surgical strategies in the Management of Cancer 19. Translational research (overview of phase I, II and III clinical trials) back to top ¡¡ Description: The Cancer Handbook is a major new reference work that provides a comprehensive overview of cancer, biology and medicine. All aspects of scientific and clinical information in cancer research and medicine are explored in this expansive resource for a wide audience including medical and life science students, as well as researchers, scientists and clinicians in the cancer field and related biomedical areas. The Cancer Handbook bridges the gap between the basic science of cancer and clinical diagnosis and ...